Peptides for Anti-Aging & Longevity
Overview
14 research peptides are currently studied for anti-aging & longevity. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.
HGH 191AA — FDA Approved
Evidence Rating: A Category: Growth Hormone
HGH 191AA refers to recombinant human growth hormone (somatropin) — a 191-amino acid, single-chain polypeptide (MW ~22,124 g/mol) identical in sequence to endogenous pituitary growth hormone. It is FDA-approved for growth hormone deficiency in children and adults, Turner syndrome, chronic renal insu...
Key claims: Treats growth hormone deficiency; Improves body composition in GH-deficient adults.
Glutathione — Meaningful Human Clinical Data
Evidence Rating: B Category: Antioxidant / Detoxification
Glutathione is a tripeptide (Glu-Cys-Gly, MW ~307.3 g/mol) and the most abundant intracellular antioxidant in mammalian cells. It is critical for Phase II detoxification, free radical scavenging, immune function, and cellular redox homeostasis. Injectable (SC/IV) glutathione bypasses the poor oral b...
Key claims: Reduces oxidative stress markers; Supports liver detoxification.
NAD+ (Nicotinamide Adenine Dinucleotide) — Early Human / Mixed Evidence
Evidence Rating: C Category: Anti-Aging / Telomere
NAD+ is a fundamental coenzyme present in all living cells that serves as a critical electron carrier in metabolic reactions and a substrate for enzymes including sirtuins, PARPs, and CD38. NAD+ levels decline approximately 50% between ages 40 and 60. While not a peptide, NAD+ and its precursors (NM...
Key claims: IV NAD+ restores youthful cellular function; NAD+ precursors (NMN/NR) slow aging.
Thymalin — Early Human or Mixed Evidence
Evidence Rating: C Category: Immune / Anti-Aging
Thymalin is a polypeptide complex isolated from calf thymus glands, developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. It has been used clinically in Russia since the 1980s for immunodeficiency states and as an anti-aging intervention. A ...
Key claims: Reduces mortality in elderly patients; Restores immune function in immunodeficiency.
Vilon — Animal/Preclinical Only
Evidence Rating: D Category: Immune / Anti-Aging
Vilon (Lys-Glu, KE) is a synthetic dipeptide (MW ~275.3 g/mol) developed by Khavinson as a simplified synthetic version of the active component in thymalin. It is one of the shortest bioregulatory peptides proposed to have immunomodulatory activity. According to Khavinson bioregulation theory, this ...
Key claims: Restores immune function in aging; Modulates gene expression via DNA binding.
Livagen — Animal/Preclinical Only
Evidence Rating: D Category: Hepatic / Anti-Aging
Livagen (Lys-Glu-Asp-Ala, KEDA) is a synthetic tetrapeptide (MW ~432.5 g/mol) developed by Khavinson as a liver-specific bioregulatory peptide. It is proposed to decondense heterochromatin in hepatocytes, reactivating genes silenced during aging and restoring hepatic function. Published studies show...
Key claims: Decondenses heterochromatin in aged hepatocytes; Restores hepatic function in aging.
Bronchogen — Animal/Preclinical Only
Evidence Rating: D Category: Respiratory / Anti-Aging
Bronchogen (Ala-Glu-Asp, AED) is a synthetic tripeptide (MW ~333.3 g/mol) from the Khavinson bioregulatory peptide family, designed as a lung-specific peptide for respiratory tissue regeneration. It is proposed to restore function of bronchial epithelium and improve respiratory parameters in aging o...
Key claims: Improves respiratory function in elderly; Promotes bronchial epithelium regeneration.
Cardiogen — Animal/Preclinical Only
Evidence Rating: D Category: Cardiovascular / Anti-Aging
Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide (MW ~489.5 g/mol) from the Khavinson bioregulatory peptide family, proposed as a cardiac-specific peptide for myocardial regeneration and cardiovascular aging. It is claimed to modulate gene expression in cardiomyocytes, improving contrac...
Key claims: Improves cardiac function in elderly; Reduces age-related cardiac fibrosis.
Pancragen — Animal/Preclinical Only
Evidence Rating: D Category: Metabolic / Anti-Aging
Pancragen (Lys-Glu-Asp-Trp, KEDW) is a synthetic tetrapeptide (MW ~562.6 g/mol) from the Khavinson bioregulatory peptide family, designed as a pancreas-specific bioregulator. It is proposed to restore beta-cell function, improve insulin secretion, and normalize glucose metabolism in aging or metabol...
Key claims: Improves glucose metabolism; Restores beta-cell function.
Vesilute — Animal/Preclinical Only
Evidence Rating: D Category: Cardiovascular / Anti-Aging
Vesilute (Lys-Glu-Asp, KED) is a synthetic tripeptide (MW ~390.4 g/mol) from the Khavinson bioregulatory peptide family, developed as a vascular-specific bioregulator. It is proposed to restore endothelial function, reduce atherosclerotic changes, and improve vascular elasticity in aging. Published ...
Key claims: Improves vascular function in aging; Reduces endothelial dysfunction.
Testagen — Animal/Preclinical Only
Evidence Rating: D Category: Hormonal / Anti-Aging
Testagen (Lys-Glu-Asp-Gly, KEDG) is a synthetic tetrapeptide (MW ~447.4 g/mol) from the Khavinson bioregulatory peptide family, designed as a testicular-specific bioregulator. It is proposed to restore Leydig cell function and testosterone production in aging males. Published primarily in Russian bi...
Key claims: Restores testosterone production in aging; Improves spermatogenesis.
Prostamax — Animal/Preclinical Only
Evidence Rating: D Category: Hormonal / Anti-Aging
Prostamax (Lys-Glu-Asp-Pro, KEDP) is a synthetic tetrapeptide (MW ~487.5 g/mol) from the Khavinson bioregulatory peptide family, designed as a prostate-specific bioregulator. It is proposed to restore prostate tissue homeostasis, reduce benign prostatic hyperplasia (BPH) symptoms, and normalize pros...
Key claims: Reduces BPH symptoms; Normalizes prostate function.