What is the difference between vasopressin and norepinephrine?

Vasopressin acts on V1a receptors to cause vasoconstriction through a catecholamine-independent mechanism, while norepinephrine acts on alpha-1 adrenergic receptors. In septic shock, vasopressin is often added to norepinephrine to provide a synergistic vasopressor effect and reduce catecholamine requirements.

Why is desmopressin preferred over vasopressin for diabetes insipidus?

Desmopressin has much greater V2 receptor selectivity and a longer half-life (approximately 2-4 hours vs 10-35 minutes for vasopressin), allowing convenient twice-daily or intranasal dosing. It also causes less V1a-mediated vasoconstriction.

Is vasopressin still used in cardiac arrest?

Vasopressin is no longer a standalone recommendation in ACLS 2020 guidelines. While it may still be used as a vasopressor in cardiac arrest, epinephrine remains the primary recommended agent.

What is the recommended dose range for Vasopressin?

The research dose range is Vasodilatory shock: 0.01-0.04 U/min (Vasostrict); Cardiac arrest: 40 U single IV dose; Diabetes insipidus: 5-10 U IM/SC 2-3 times daily, administered via Intravenous infusion, Continuous IV infusion for shock; intermittent for other indications.

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Vasopressin Dosing & Reconstitution Guide

Complete dosing reference for Vasopressin (Reproductive / Hormonal). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Intravenous infusion Frequency: Continuous IV infusion for shock; intermittent for other indications Dose Range: Vasodilatory shock: 0.01-0.04 U/min (Vasostrict); Cardiac arrest: 40 U single IV dose; Diabetes insipidus: 5-10 U IM/SC 2-3 times daily

Timeline & Pharmacokinetics

Onset: Immediate (IV) Half-Life: 10-35 minutes Washout: 1-2 hours

Storage

Lyophilized: Not applicable (supplied as solution) Reconstituted: Store at 20-25 °C (68-77 °F); do not freeze

Safety & Contraindications

Safety: Peripheral and splanchnic ischemia: digital ischemia, mesenteric ischemia, and skin necrosis reported with higher doses Cardiac ischemia: coronary vasoconstriction may precipitate angina or myocardial infarction Hyponatremia: excessive water retention via V2 receptor stimulation

Contraindications: Hypersensitivity to vasopressin or any component; Use with caution in patients with coronary artery disease (risk of myocardial ischemia); Use with caution in peripheral vascular disease (risk of limb ischemia)

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.