What is a Khavinson peptide bioregulator?

Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology have developed a series of short peptides (2-4 amino acids) claimed to regulate gene expression in specific tissues. These include Epithalon (pineal), Pinealon (brain/pineal), Cortagen (brain cortex), Vilon (immune), and others. Their claims are primarily supported by research from the developing laboratory, with limited independent validation.

Is there clinical evidence for pinealon?

No rigorous clinical evidence exists. Available data consists of preclinical cell culture and animal studies plus small, open-label, uncontrolled clinical observations — all from the Khavinson research group. No randomized controlled trials have been published.

Safety has not been systematically evaluated. The small size and simple amino acid composition of the tripeptide suggest low acute toxicity, but without controlled studies, the safety profile remains unknown. It should not be used in place of proven medical treatments.

What is the recommended dose range for Pinealon?

The research dose range is 10–20 mg/day sublingual or capsule, administered via Oral (sublingual) or Intranasal, 1–2 times daily.

peptide dosing

Pinealon Dosing & Reconstitution Guide

Complete dosing reference for Pinealon (Nootropic / Neuroprotective). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Oral (sublingual) or Intranasal Frequency: 1–2 times daily Dose Range: 10–20 mg/day sublingual or capsule

Safety & Contraindications

Safety: No controlled safety studies have been conducted No serious adverse effects reported in Russian open-label observations Long-term safety is unknown

Contraindications: Pregnancy and breastfeeding (no safety data); No established contraindications due to absence of clinical data; Not recommended for use in place of evidence-based treatments for neurological conditions

Related Research News

Regulatory

Pinealon: Neuroprotective Tripeptide Research Guide

Pinealon, a synthetic tripeptide known as Glu-Asp-Arg or EDR, targets the central nervous system for neuroprotection. Developed by Vladimir Khavinson's team at the St. Petersburg Institute of Bioregulation and Gerontology, it shows effects on gene expression, cell proliferation, and protection against oxidative stress in neuronal models. Studies highlight reduced apoptosis, preserved mitochondrial function, and potential benefits in hypoxia and aging contexts, though much data comes from one research group.

May 12, 2026

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.