Oxytocin Dosing & Reconstitution Guide
Dosing Protocol
Route: Intravenous infusion (labor); Intramuscular injection (PPH); Intranasal spray (research) Frequency: Continuous IV infusion for labor; single IM dose for PPH prophylaxis Dose Range: Labor induction: 0.5-2 mU/min initial, titrated up to 20-40 mU/min; PPH prophylaxis: 10 IU IM; Intranasal (research): 24 IU Timing: Labor induction: increase by 1-2 mU/min every 30-60 minutes until adequate contraction pattern
Timeline & Pharmacokinetics
Onset: 1 minute (IV); 3-5 minutes (IM) Peak Plasma: Immediate (IV) Half-Life: 1-6 minutes Washout: 30-60 minutes
Storage
Lyophilized: Not applicable (supplied as solution) Reconstituted: Store at 20-25 °C (68-77 °F); refrigerate after opening multi-dose vials
Safety & Contraindications
Safety: Uterine hyperstimulation/tachysystole: can cause excessive contractions leading to fetal distress; requires continuous fetal monitoring Water intoxication and hyponatremia: oxytocin has antidiuretic properties at high doses; risk increases with prolonged infusion and hypotonic IV fluids Uterine rupture: rare but life-threatening, especially in patients with prior uterine surgery
Contraindications: Significant cephalopelvic disproportion or unfavorable fetal position; Placenta previa or vasa previa; Prior classical (vertical) cesarean section or major uterine surgery
Related Products
MOTS-C 20mg
20mg
Related Research News
Oxytocin's Vital Role in Social and Relationship Bonds
Oxytocin, known as the love hormone, supports social connections through release during touch, trust, and intimacy. Research indicates it aids trust, empathy, and bonding in romantic, parental, and friendly relationships, though effects depend on context and individual factors. This peptide also interacts with stress systems to promote emotional regulation and well-being.
Atosiban Serves as Maintenance Therapy for Preterm Labor
Atosiban, an oxytocin-receptor antagonist marketed in China in 2006, offers maintenance treatment to manage preterm labor risks after initial tocolysis. Clinical trials show it delays delivery better than placebo in some cases and has fewer side effects than beta-2 agonists. Studies highlight its safety and role in reducing recurrent preterm labor episodes.