MOTS-c Dosing & Reconstitution Guide
Dosing Protocol
Route: Subcutaneous Frequency: Once daily or 3–5x weekly Dose Range: 5–10 mg SC per injection Cycle Length: 4–8 weeks; cycling protocols vary Timing: Morning or before exercise for metabolic activation
Reconstitution
Vial Size: 10mg Water Volume: 2mL Concentration: 5mg/mL
Titration Schedule
Weeks 1–2: 5 mg daily or 3x weekly Weeks 3+: 10 mg daily or 5x weekly
Timeline & Pharmacokinetics
Onset: Hours to days (metabolic effects) Half-Life: Not well characterized in humans Time to Results: 4–8 weeks for metabolic improvements
Storage
Lyophilized: −20 °C (−4 °F) Reconstituted: 2–8 °C (35.6–46.4 °F) Shelf Life: 28 days
Injection Sites
Abdomen, Thigh
Safety & Contraindications
Safety: No adverse effects reported in preclinical animal studies Human tolerability is completely unknown for native MOTS-c (no completed human trials) Modified analog CB4211 showed good tolerability in Phase 1
Contraindications: No established contraindications due to absence of human clinical data; Caution in diabetics on glucose-lowering medication (potential additive hypoglycemia based on mechanism); Pregnancy and breastfeeding (no data)
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