What is larazotide used for?

Larazotide is being developed as an adjunct therapy for celiac disease. It is designed to reduce intestinal permeability caused by gluten exposure, not to replace a gluten-free diet. It would be used alongside dietary management to provide additional protection against inadvertent or small-amount gluten exposure.

Does larazotide cure celiac disease?

No. Larazotide does not treat the underlying autoimmune pathology. It reduces the tight junction opening that allows gluten peptides to cross the intestinal barrier, potentially reducing symptom flares from inadvertent gluten exposure. A gluten-free diet remains essential.

Is larazotide absorbed into the bloodstream?

In clinical trials, larazotide was not detectable in plasma at therapeutic doses, indicating it acts locally in the intestinal lumen with minimal to no systemic absorption. This is a favorable safety feature.

What is the recommended dose range for Larazotide?

The research dose range is 0.5 mg TID (optimal dose from Phase IIb), administered via Oral, Three times daily (TID) before meals.

peptide dosing

Larazotide Dosing & Reconstitution Guide

Complete dosing reference for Larazotide (Healing & Recovery). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Oral Frequency: Three times daily (TID) before meals Dose Range: 0.5 mg TID (optimal dose from Phase IIb)

Storage

Lyophilized: N/A (capsule formulation) Reconstituted: N/A

Safety & Contraindications

Safety: Well tolerated across Phase I, II, and III trials Adverse event rates similar to placebo in controlled trials No significant systemic absorption detected at therapeutic doses

Contraindications: Known hypersensitivity to larazotide or excipients; Not a substitute for a gluten-free diet in celiac disease; Pregnancy and breastfeeding (no safety data)

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.