How does KPV differ from Melanotan peptides?

KPV is the C-terminal fragment of α-MSH and does NOT cause skin darkening. Melanotan I and II are full melanocortin receptor agonists that cause pigmentation. KPV works through the PepT1 transporter, not melanocortin receptors, so it provides anti-inflammatory benefits without tanning effects.

Can KPV be taken orally?

Yes. Oral KPV is commonly used for gut inflammation because the PepT1 transporter in intestinal cells actively imports it. PepT1 is upregulated during gut inflammation, creating a self-targeting mechanism. Typical oral doses are 200-500 mcg, 1-2 times daily.

No. KPV has no FDA approval and has not completed formal clinical trials in humans. It was removed from FDA Category 2 on April 15, 2026, and PCAC review is scheduled for July 2026.

What is the recommended dose range for KPV?

The research dose range is Oral: 200-500 mcg/day; SC: 100-500 mcg/day; Topical: 0.01-0.1% preparation, administered via Oral (gut), Subcutaneous (systemic), Topical (skin), 1-2 times daily.

peptide dosing

KPV Dosing & Reconstitution Guide

Complete dosing reference for KPV (Anti-Inflammatory / Immune). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Oral (gut), Subcutaneous (systemic), Topical (skin) Frequency: 1-2 times daily Dose Range: Oral: 200-500 mcg/day; SC: 100-500 mcg/day; Topical: 0.01-0.1% preparation Cycle Length: 4-8 weeks Timing: Oral: before meals on empty stomach; SC: morning or evening

Storage

Lyophilized: -20 °C (-4 °F) Reconstituted: 2-8 °C (35.6-46.4 °F) Shelf Life: 21 days

Safety & Contraindications

Safety: No significant adverse effects reported in preclinical studies Does not cause skin darkening (unlike Melanotan peptides) No formal human safety trials have been conducted

Contraindications: Pregnancy and breastfeeding (no safety data); Known hypersensitivity to α-MSH-derived peptides; Immunosuppressed patients (theoretical — anti-inflammatory mechanism)

Related Products

In Stock

KPV 10mg

10mg

Application formLyophilized powder

StorageRefrigerated

Purity98%

AppearanceLyophilized powder

$34 USD

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.