Why does GHRP-6 make you so hungry?

GHRP-6 strongly activates the ghrelin receptor (GHS-R1a), which is the primary appetite-stimulating receptor. This effect is more pronounced than with GHRP-2 or ipamorelin, which are more selective.

How does GHRP-6 compare to ipamorelin?

GHRP-6 is less selective: it raises GH but also increases cortisol, prolactin, and appetite significantly. Ipamorelin is more selective for GH release with fewer side effects. GHRP-6 may be preferred when appetite stimulation is desired.

Can GHRP-6 be combined with GHRH?

Yes. Studies show synergistic effects when GHRP-6 is combined with GHRH (e.g., CJC-1295 or Mod GRF 1-29), producing GH responses greater than either alone. This synergism is preserved in most patient populations.

What is the recommended dose range for GHRP-6?

The research dose range is 100–300 mcg per injection, 2–3x daily (saturation dose ~1 mcg/kg), administered via Subcutaneous, 2–3 times daily.

peptide dosing

GHRP-6 Dosing & Reconstitution Guide

Complete dosing reference for GHRP-6 (Growth Hormone Secretagogue). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous Frequency: 2–3 times daily Dose Range: 100–300 mcg per injection, 2–3x daily (saturation dose ~1 mcg/kg) Cycle Length: 8–12 weeks on, 4 weeks off Timing: On empty stomach; 30 min before meals and/or before bed

Reconstitution

Vial Size: 5mg Water Volume: 2.5mL Concentration: 2mg/mL

Titration Schedule

Weeks 1–2: 100 mcg 2x daily Weeks 3+: 100–300 mcg 2–3x daily

Timeline & Pharmacokinetics

Onset: 15–30 minutes Peak Plasma: 15–60 minutes (GH peak ~30 min post-injection) Half-Life: ~15–20 minutes Steady State: 2–4 weeks of daily dosing Time to Results: 2–4 weeks for appetite/sleep changes; 8–12 weeks for body composition Washout: 1–2 weeks

Storage

Lyophilized: −20 °C (−4 °F) Reconstituted: 2–8 °C (35.6–46.4 °F) Shelf Life: 28 days

Injection Sites

Abdomen, Thigh

Safety & Contraindications

Safety: Intense hunger due to ghrelin receptor activation (more pronounced than other GH secretagogues) Transient mild increases in cortisol and ACTH (typically not clinically significant) Water retention and bloating reported

Contraindications: Active malignancy (GH/IGF-1 elevation contraindicated); Pregnancy and breastfeeding; Pituitary disorders

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.