All Comparisons
MK-677 vs CJC-1295
Side-by-side comparison of evidence, mechanisms, dosing, safety, and regulatory status.
MK-677: CCJC-1295: D
| Attribute | MK-677 | CJC-1295 |
|---|---|---|
| Category | Growth Hormone Secretagogue | Growth Hormone Secretagogue |
| Evidence Rating | C — Phase I–II Clinical Trials | D — Preclinical |
| Clinical Status | Multiple Phase II trials completed. Not FDA-approved. Investigational. | Research-only / Not approved for human use |
| Mechanism | MK-677 binds to the ghrelin receptor (GHS-R1a) in the pituitary gland and hypothalamus, mimicking the hunger hormone ghrelin. This activates the GH secretagogue pathway, amplifying the natural pulsatile release of growth hormone and subsequently IGF-1, without suppressing the hypothalamic-pituitary ... | CJC-1295 binds to GHRH receptors (GHRHR) on pituitary somatotroph cells, activating intracellular cAMP signaling to stimulate both the transcription of the GH gene and pulsatile release of endogenous growth hormone, which in turn increases IGF-1 levels. The released IGF-1 travels to muscle tissue fo... |
| Half-Life | ~4–6 hours (plasma); functional activity ~24 hours | No DAC (mod GRF 1-29): ~30 min; With DAC: ~8 days |
| Bioavailability | Orally bioavailable | — |
| Molecular Weight | ~528.7 g/mol (624.8 as mesylate salt) | No DAC: ~3367.9 g/mol; With DAC: ~3647.3 g/mol |
| WADA Status | Prohibited | Prohibited |
| Dosing | 10–25 mg/day orally, Once daily (Oral (capsule or liquid)) | No DAC: 100 mcg before bed daily; DAC: 1–2 mg 2–3x weekly, Once daily (no DAC) or 2–3 times weekly (with DAC) (Subcutaneous) |
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| Regulatory (US) | Not FDA-approved. Removed from FDA Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026. Investigational compound. Available as a research chemical. Not a controlled substance. | Not FDA-approved. Research chemical only. WADA-banned under Section S2 (growth factors and related substances). |
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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