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GHRP-2 vs GHRP-6

Side-by-side comparison of evidence, mechanisms, dosing, safety, and regulatory status.

GHRP-2: CGHRP-6: D
AttributeGHRP-2GHRP-6
CategoryGrowth Hormone SecretagogueGrowth Hormone Secretagogue
Evidence RatingC — Phase I–II Clinical TrialsD — Preclinical
Clinical StatusApproved in Japan for GH deficiency diagnosis; research-only elsewhereResearch-only / Not approved for human use
MechanismGHRP-2 (C45H55N9O6) binds to and activates ghrelin (GH secretagogue) receptors on pituitary somatotrophs, triggering robust pulsatile GH release. In healthy adults, 100 mcg SC daily produces acute GH stimulation. Unlike continuous GH, GHRP-2 maintains physiological feedback controls. Once-daily admi...GHRP-6 functions as a synthetic ghrelin mimetic by binding to GHS-R1a in the pituitary and hypothalamus, triggering pulsatile GH release and raising IGF-1 levels. Unlike continuous GH administration, GHRP-6 maintains physiological feedback: as GH and IGF-1 rise, endogenous somatostatin increases to ...
Half-Life~15–60 minutes~15–60 minutes
Bioavailability——
Molecular Weight~817.0 g/mol~873.0 g/mol
WADA StatusProhibitedProhibited
Dosing100–300 mcg per injection, 2–3x daily, 2–3 times daily (Subcutaneous)100–300 mcg per injection, 2–3x daily (saturation dose ~1 mcg/kg), 2–3 times daily (Subcutaneous)
Key Use Cases
  • Body Composition
  • Body Composition
Safety Concerns
  • Well tolerated in clinical trials with placebo-like safety profile at therapeutic ranges
  • May increase appetite (less than GHRP-6)
  • Can elevate cortisol and prolactin levels (less than GHRP-6)
  • Intense hunger due to ghrelin receptor activation (more pronounced than other GH secretagogues)
  • Transient mild increases in cortisol and ACTH (typically not clinically significant)
  • Water retention and bloating reported
Contraindications
  • Active malignancy (GH/IGF-1 elevation contraindicated)
  • Pregnancy and breastfeeding
  • Pituitary disorders (outside diagnostic context)
  • Diabetes and cardiovascular conditions (GH affects glucose metabolism)
  • Active malignancy (GH/IGF-1 elevation contraindicated)
  • Pregnancy and breastfeeding
  • Pituitary disorders
  • Conditions worsened by increased appetite, cortisol, or fluid retention
Regulatory (US)Not FDA-approved. Research chemical only. Banned by WADA.Not FDA-approved. Research chemical only.

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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