All Comparisons
CJC-1295 vs Sermorelin
Side-by-side comparison of evidence, mechanisms, dosing, safety, and regulatory status.
CJC-1295: DSermorelin: C
| Attribute | CJC-1295 | Sermorelin |
|---|---|---|
| Category | Growth Hormone Secretagogue | Growth Hormone Secretagogue |
| Evidence Rating | D — Preclinical | C — Phase I–II Clinical Trials |
| Clinical Status | Research-only / Not approved for human use | Previously FDA-approved (Geref, discontinued); now used off-label via compounding |
| Mechanism | CJC-1295 binds to GHRH receptors (GHRHR) on pituitary somatotroph cells, activating intracellular cAMP signaling to stimulate both the transcription of the GH gene and pulsatile release of endogenous growth hormone, which in turn increases IGF-1 levels. The released IGF-1 travels to muscle tissue fo... | Sermorelin binds to GHRH receptors (GHRHR) on somatotroph cells in the anterior pituitary gland, stimulating both transcription of the HGH gene and pulsatile release of endogenous growth hormone. The released HGH increases protein synthesis, fat breakdown (lipolysis), and tissue repair across multip... |
| Half-Life | No DAC (mod GRF 1-29): ~30 min; With DAC: ~8 days | ~10–20 minutes |
| Bioavailability | — | — |
| Molecular Weight | No DAC: ~3367.9 g/mol; With DAC: ~3647.3 g/mol | ~3357.9 g/mol |
| WADA Status | Prohibited | Prohibited |
| Dosing | No DAC: 100 mcg before bed daily; DAC: 1–2 mg 2–3x weekly, Once daily (no DAC) or 2–3 times weekly (with DAC) (Subcutaneous) | 100–300 mcg/day SC, Once daily (typically before bed) (Subcutaneous) |
| Key Use Cases |
|
|
| Safety Concerns |
|
|
| Contraindications |
|
|
| Regulatory (US) | Not FDA-approved. Research chemical only. WADA-banned under Section S2 (growth factors and related substances). | Previously FDA-approved (Geref) for pediatric GH deficiency; voluntarily discontinued by manufacturer for commercial reasons. FDA confirmed in 2013 it was not withdrawn for safety. Available via compounding pharmacies. WADA-banned. |
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
Explore More
Comparisons
Compare any two peptides side-by-side or browse our curated popular matchups.